Hening Lin

Professor

Summary

The Lin Group, an HHMI chemical biology lab at Cornell,  studies the chemistry, biology, and application of enzymes that have important physiological functions with a combination of synthetic and biochemical methods.

Research Focus

  • The chemistry, biology, and application of enzymes
  • Enzymes of particular interest are sirtuins, HDACs, PARPs, radical SAM enzymes, and CD38. Most of these enzymes are involved in protein post-translational modifications and have important biological functions.
  • We combine organic synthesis, biochemistry, biophysics, molecular biology, and cell biology to study the enzymology, identify the modified proteins, and study how the modification affects protein structure/function and thus the biological significance of the modification. We also develop small molecule inhibitors to target these enzymes and investigate their potentials in treating human diseases, such as cancer.

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