Kyle M. Lancaster

Overview

The Lancaster Group employs synthesis, biochemistry, and a broad range of spectroscopic methods––with an emphasis on synchrotron-based core spectroscopies––to explore reactivity mediated by transition metal complexes and metalloenzymes. The group currently focuses on transformations pertinent to the biogeochemical nitrogen cycle and to C–H functionalization.

More information and the group's latest news can be found at here.

Selected Awards/Honors

Publications

Bioinorganic Chemistry of the Nitrogen Cycle

• Rathnayaka, S.C.; Islam, S.M.; DiMucci, I.M.; MacMillan, S.N.; Lancaster, K.M.; Mankad, N.P. Probing the electronic and mechanistic roles of the μ₄-sulfur atom in a synthetic Cu_Z model system, Chem. Sci. 2020, 11, 3441-3447.
• Coleman, R.E.; Vilbert, A.C.; Lancaster, K.M. The Heme–Lys Cross-Link in Cytochrome P460 Promotes Catalysis by Enforcing Secondary Coordination Sphere Architecture, Biochemistry 2020, 59, 2289-2298.
• Ferousi, C.; Majer, S.H.; DiMucci, I.M.; Lancaster, K.M. Biological and Bioinspired Inorganic N–N Bond-Forming Reactions, Chem. Rev. 2020, 120, 5252-5307.
• Smith, M.A.; Majer, S.H.; Vilbert, A.C.; Lancaster, K.M. Controlling a burn: outer-sphere gating of hydroxylamine oxidation by a distal base in cytochrome P460, Chem. Sci. 2019, 10, 3756-3764.
• Lancaster, K.M.; Caranto, J.D.; Majer, S.H.; Smith, M.A. Alternative Bioenergy: Updates to and Challenges in Nitrification Metalloenzymology, Joule 2018, 2, 421–441.
• Vilbert, A.C.; Caranto, J.D; Lancaster, K.M. Influences of the Heme-lysine Crosslink in Cytochrome P460 over Redox Catalysis and Nitric Oxide Sensitivity, Chem. Sci. 2018, 9, 368–379.
• Caranto, J.D.; Lancaster, K.M. Nitric Oxide is an Obligate Bacterial Nitrification Intermediate Produced by Hydroxylamine Oxidoreductase. Proc. Natl. Acad. Sci. U.S.A. 2017, 31, 8217–8222.
• Caranto, J. D.; Vilbert, A. C.; Lancaster, K. M. Nitrosomonas europaea Cytochrome P460 Is a Direct Link between Nitrification and Nitrous Oxide Emission. Proc. Natl. Acad. Sci. USA, 2016, 113, 14704–14709.

Transition Metal Electronic Structure/X-ray Spectroscopy

• DiMucci, I.M.; Lukens, J.T.; Chatterjee, S.; Carsch, K.M.; Titus, C.J.; Lee, S.J.; Nordlund, D.; Betley, T.A.; MacMillan, S.N.; Lancaster, K.M. The Myth of d⁸ Copper(III), J. Am. Chem. Soc. 2019, 141, 18508-18520.
• MacLeod, K.C.; DiMucci, I.M.; Zovinka, E.P.; McWilliams, S.F.; Mercado, B.Q.; Lancaster, K.M.; Holland, P.L., Masked Radicals: Iron Complexes of Trityl, Benzophenone, and Phenylacetylene, Organometallics 2019, 38, 4224-4232.
• Carsch, K.M.; DiMucci, I.M.; Iovan, D.A.; Li, A.; Zheng, S.; Titus, C.J.; Lee, S.J.; Irwin, K.D.; Nordlund, D.; Lancaster, K.M.; Betley, T.A., Synthesis of a copper-supported triplet nitrene complex pertinent to copper-catalyzed amination, Science 2019, 365, 1138-1143.
• Lukens, J.T.; DiMucci, I.M.; Kurogi, T.; Mindiola, D.J.; Lancaster, K.M., Scrutinizing metal–ligand covalency and redox non-innocence via nitrogen K-edge X-ray absorption spectroscopy, Chem. Sci. 2019, 10, 5044–5055.
• MacMillan, S. N.; Lancaster, K. M. X-ray Spectroscopic Interrogation of Transition Metal-Mediated Homogeneous Catalysis: Primer and Case Studies. ACS Catalysis, 2017, 7, 1776–1791.
• Walroth, R. C.; Lukens, J. T.; MacMillan, S. N.; Finkelstein, K. D.; Lancaster, K. M. Spectroscopic Evidence for a 3d¹⁰ Ground State Electronic Configuration and Ligand Field Inversion in [Cu(CF₃)₄]^1– J. Am. Chem. Soc. 2016, 138, 1922–1931.

In the news

• Causing reactions: Klarman Fellow develops new catalysts
• Arts and Sciences faculty honored for teaching, advising excellence
• A&S announces third cohort of Klarman Fellows
• Prof wins national chemistry award
• Merrill scholars honor their mentoring teachers, professors
• New study shows photosynthesis more efficient than believed
• Passionate explorers - a chemistry story
• Nitric oxide plays key role in forming potent greenhouse gas
• Intrigued by chemistry
• Brito, Lambert, Yapici, Lancaster receive Sloan Fellowships