Research in the Lambert group is focused in the area of catalysis. We are especially interested in the development of novel catalytic strategies for selective organic synthesis. Projects that we have been active in include electrophotocatalysis, catalytic carbonyl-olefin metathesis, and the study of aromatic ions. In approaching these and other problems, we strive to develop highly effective practical solutions while asking interesting questions of reactivity and mechanism. We bring both synthetic and physical organic techniques to bear on answering these questions as we work to develop catalyst systems of practical value for the field of organic synthesis.
- Metal–Free Ring–Opening Metathesis Polymerization with Hydrazonium Initiators. Quach, P.; Hsu, J. H.; Keresztes, I.; Fors, B. P.; Lambert, T. H. Angew. Chem. Int. Ed. 2022, 61, Early view.
- Electrophotocatalytic Diamination of Vicinal C–H Bonds. Science 2021, 371, 620-626.
- Hydrogen Bond Donor Catalyzed Cationic Polymerization of Vinyl Ethers. Kottisch, V.; Jermaks, J.; Mak, J.-Y.; Woltornist, R. A.; Lambert, T. H.; Fors, B.P. Angew. Chem. Int. Ed. 2021, 60, 4535-4539.
- Ring-Opening Carbonyl-Olefin Metathesis of Norbornenes. Chem. Sci. 2020, 11, 7884-7895.
- Reductive Electrophotocatalysis: Merging Electricity and Light to Achieve Extreme Reduction Potentials. Kim, H.; Kim, H.; Lambert, T. H.; Lin, S. J. Am. Chem. Soc. 2020, 142, 2087-2092.
- Room Temperature, Base-Free SNAr Reactions with Unactivated Aryl Fluorides. Huang, H.; Lambert, T. H. Angew. Chem. Int. Ed. 2020, 59, 658-662.
- Electrophotocatalysis with a Trisaminocyclopropenium Radical Dication. Huang, H.; Strater, Z. M.; Rauch, M.; Shee, J.; Sisto, T. J.; Nuckolls, C.; Lambert, T. H. Angew. Chem. Int. Ed. 2019, 58, 13318-13322.
- An Aromatic Ion Platform for Enantioselective Brønsted Acid Catalysis. Gheewala, C. D.; Collins, B. E.; Lambert, T. H. Science 2016, 351, 961-965.