Overview
Thomas D. Fox received his B.S. degree from Cornell University in 1971 and his Ph.D. in Biochemistry and Molecular Biology from Harvard University in 1976.
Research Focus
I am no longer actively engaged in laboratory research. Our research was aimed at understanding how expression of genes in mitochondrial DNA is controlled by nuclear genes, and how mitochondrially coded proteins are assembled with nuclearly coded proteins into the respiratory chain complexes. Budding yeast (Saccharomyces cerevisiae) is a wonderful organism in which to study these interactions, since mutations in both genetic systems can be isolated and manipulated. Furthermore, genetic transformation and homologous recombination allow the replacement of wild-type by mutant, or novel, DNA sequences in both the nuclear and mitochondrial genomes.
