Human Diseases and Ubiquitination

Ubiquitin is an essential amino acid protein that modifies other proteins in eukaryotes. These modifications, or ubiquitination, play an essential role in a broad number of cellular processes, including transcription, DNA repair, signal transduction, autophagy, cell cycle, immune response, and membrane trafficking. It follows that aberration in the mechanisms of ubiquitination can lead to a number of human diseases—specifically, neurodegenerative diseases and cancers.

Yuxin Mao, Molecular Biology and Genetics, has discovered one way that bacteria target and manipulate these essential processes and is working to uncover the precise molecular mechanisms.

Continue this article about his work on Cornell Research.

Photo Credit: Beatrice Jin

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